Mission: Orchestra of St. Luke's (OSL) presents over 70 concerts, programs, and events in a variety of diverse musical genres every season, including an annual Carnegie Hall Orchestra Series, a full Chamber Music Series, Free Community Concerts serving all five boroughs, and Free School Concerts that reach over 11,000 public schoolchildren. OSL puts classical music performances and training within reach for all New Yorkers through its innovative and accessible Education & Community programs. OSL provides rehearsal, recording, education, and performance space through The DiMenna Center for Classical Music, its home in New York City's Hell's Kitchen neighborhood.

Orchestra of St. Luke's is a 501(c)(3) organization, with an IRS ruling year of 1976, and donations are tax-deductible.